Endocrine Abstracts

Background: The relationships between thyroid hormones (TH) and platelets (PLT) have not been fully established. Physiological concentrations of L-thyroxine (T4) activate human PLT resulting in ATP release and aggregation. On the other hand, subclinical hypothyroidism has been frequently associated with hypercoagulability, in particular mean platelet volume (MPV), a marker of platelet activation, has been found higher in patients with subclinical hypothyroidism. A possible pro...

Introduction: The prevalence of obesity and metabolic disturbances is worryingly increasing worldwide, therefore the study of their pathophysiology is extremely important to find new strategies for their treatment. Obesity has an impact not only on the metabolism of the patients, but also profoundly influence their daily life, and potentially affect the quality of life and the quality of sleep. These latter are strictly related to the circadian rhythm of the individuals that, ...

Introduction: The chronic reduction of sleep duration is associated to an increased risk of weight gain, but mechanistic aspects remain to be fully elucidated. The aim of our study was to examine the relationship between short sleep duration and energy metabolism, fuel selection and energy balance in overweight and obesity. Methods: Inclusion criteria were: age 18–65 years, BMI ≥25 kg/m2. Use of any CNS medications, any psychiatric disorders and night shi...

Background: Metabolic syndrome (MS) is associated with increased mortality, and the key factors predictive of its development among patients with obesity are still unclear. We recently demonstrated with a machine learning approach that Insulin-like Growth Factor 1 (IGF-1) is a novel marker of metabolic health and that in individuals with obesity, lower IGF-1 levels are associated with increased metabolic deterioration. However, the interpretation of IGF-1 serum measurement is ...

Purpose: From a clinical perspective, the full spectrum of Sars–CoV–2–infected patients has not yet been defined. This study aimed to evaluate whether liver density on computed tomography (CT) scan and serum insulin-like growth factor 1 (IGF1) values can explain the clinical variability of COVID–19 cases.Methods: We performed a retrospective study including SARS–CoV–2–infected patients hospitalized from March 2020 to Ma...

Background and aim: Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. SIRT1 pharmacological induction improves bone quality both in murine and human models and- as adiposity increases – its expression decreases both in peripheral tissues and blood. Sclerostin reduces osteoblasts’ differentiation and mineralization and is associated with DMT2, obesity and cardiovascular risk. We evaluated the circulating SIRT1 and sclerostin r...

Case Summary: In May 2018, a 22-year-old man was admitted to the Emergency Room of Polyclinic Umberto I Hospital of Rome, because of progressive headaches and binocular diplopia. Brain MRI revealed a heterogeneous T1WI-hypointense and T2WI-hyperintense mass of 40x28x25 mm (CC, LL, AP) including calcification areas in the left paramedian region of the clivus invading the homolateral cavernous sinus. The patient underwent partial tumour resection via infratemporal approach and a...

Background and aim: Dual energy X-ray absorptiometry (DXA) is considered the gold standard to evaluate BC, even if it requires the use of radiations, an expensive equipment and cannot be performed at the patient’s bedside. Nutritional ultrasound (NU) evaluates BC through the assessment of muscle mass and the abdominal subcutaneous (superficial and deep-layer) and visceral adipose tissue. We aimed at comparing the accuracy and reliability of this emerging tool with DXA in ...

Introduction: In overweight and obesity energy unbalance is responsible for the accumulation of ectopic fat. Excess energy and metabolic alterations, namely insulin resistance, may favor ectopic fat depositions. However, the role played by dietary factors, especially the pro-inflammatory properties of dietary patterns, in ectopic fat storage is not thoroughly understood. The aim of our study was to investigate the association between the Dietary Inflammatory Index (DII) and di...

Obesity is associated with hemodynamic alterations that may lead to heart failure (HF), through the development of cardiac structural abnormalities and impairment of ventricular function. Obesity-related neurohormonal and metabolic disturbances may predispose to HF, even in the absence of comorbidities. Excess adipose tissue and in particular visceral adiposity contributes to the altered production of a number of anabolic hormones also involved in the regulation of the cardiac...